Design and Synthesis of Some Novel 4-(4-substituted aryl) Semicarbazones as Anticonvulsant Agents
نویسندگان
چکیده
In the present study, a series of 4-(4-substituted aryl) semicarbazones were synthesized from substituted anilines and subsequently evaluated for their anticonvulsant activities. The anticonvulsant activities were established by the anticonvulsant drug development (ADD) programme NIH, USA using experimental animal, adult male FCM mice (20-25 g) and adult Sprague-Dawley rats (100-150 g) and screened against electroshock seizure, subcutaneous metrazole and minimal neurotoxicity tests in mice. Compound 7 was found equipotent to carbamazepine in both MES and ScPTZ tests. This study has highlighted the importance of distal alkyl chain which influences the anticonvulsant activity.
منابع مشابه
Synthesis of 4 – aryl substituted semicarbazones and their terpenes derivatives : A newer scaffold as an anticonvulsant agents
A series of 4 – aryl substituted semicarbazones of some terpenes ie , citral ( acyclic terpene ) , camphor ( bicyclic terpene ) and menthone ( monocyclic terpene ) were synthesized from substituted anilines , to meet the structural requirements essential for anticonvulsant activity . The structures of the synthesized terpene semicarbazones were confirmed by I.R. , H-NMR and elemental analysis. ...
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متن کاملDesign and Synthesis of 4-flurophthalimides as potential anticonvulsant agents
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